GNF remains committed to the public dissemination of the results of its fundamental research programs through timely scientific publication as well as open access to many of its most signficant tools and databases. Listed below are representative samples of recent GNF publications.
Please click here for a full list of GNF's publications.
· Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.
Tao H, Jin Q, Koo DI, Liao X, Englund NP, Wang Y, Ramamurthy A, Schultz PG, Dorsch M, Kelleher J, Wu X.
Chem Biol. 2011 Apr; 18(4): 432-7.
· Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression.
Xiao B, Coste B, Mathur J, Patapoutian A.
Nat Chem Biol. 2011 Apr;
Xiao B, Coste B, Mathur J, Patapoutian A.
Nat Chem Biol. 2011 Apr;
· Identification of a high affinity ligand that exhibits complete Ah receptor antagonism.
Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson W, Kolluri SK, Cooke MP, Perdew GH.
J Pharmacol Exp Ther. 2011 Apr;
Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson W, Kolluri SK, Cooke MP, Perdew GH.
J Pharmacol Exp Ther. 2011 Apr;
· Structure and function of the first full-length murein Peptide ligase (mpl) cell wall recycling protein.
Das D, Hervé M, Feuerhelm J, Farr CL, Chiu HJ, Elsliger MA, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA.
PLoS One. 2011 Mar; 6(3)
Das D, Hervé M, Feuerhelm J, Farr CL, Chiu HJ, Elsliger MA, Knuth MW, Klock HE, Miller MD, Godzik A, Lesley SA, Deacon AM, Mengin-Lecreulx D, Wilson IA.
PLoS One. 2011 Mar; 6(3)
· Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin.
Nam TG, Lee J, Walker JR, Brinker A, Cho CY, Schultz PG. ChemMedChem. 2011 Mar;
Nam TG, Lee J, Walker JR, Brinker A, Cho CY, Schultz PG. ChemMedChem. 2011 Mar;
· Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα Grandinetti KB, Stevens TA, Ha S, Salamone RJ, Walker JR, Zhang J, Agarwalla S, Tenen DG, Peters EC, Reddy VA. Oncogene. 2011 Mar;
· Small-molecule regulators of human stem cell self-renewal.
Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG. Chembiochem. 2011 Apr; 12(6): 854-7.
Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG. Chembiochem. 2011 Apr; 12(6): 854-7.
· A concise synthesis of paucifloral F and related indanone analogues via palladium-catalyzed α-arylation.
Yang Y, Philips D, Pan S. J Org Chem. 2011 Mar; 76(6): 1902-5.
Yang Y, Philips D, Pan S. J Org Chem. 2011 Mar; 76(6): 1902-5.
· An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity .
Young DD, Young TS, Jahnz M, Ahmad I, Spraggon G, Schultz PG. Biochemistry. 2011 Mar; 50(11): 1894-900.
Young DD, Young TS, Jahnz M, Ahmad I, Spraggon G, Schultz PG. Biochemistry. 2011 Mar; 50(11): 1894-900.
· Chemical control of stem cell fate and developmental potential.
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Angew Chem Int Ed Engl. 2011 Jan; 50(1): 200-42.
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Angew Chem Int Ed Engl. 2011 Jan; 50(1): 200-42.
