The successful candidate will play an important role in establishing a portfolio of preclinical drug discovery programs targeting orphan muscular and neuromuscular diseases including Duchenne muscular dystrophy (DMD), myotonic dystrophy (DM), spinal muscular atrophy (SMA) and amyotropic lateral sclerosis (ALS), investigating approaches involving muscle regeneration, preventing atrophy/fibrosis and initiating new lead discovery projects targeting established and novel molecular pathways. 

Responsibilities:

• Identifying and proposing new drug discovery targets
• Developing and optimizing biochemical or cell-based assays for hit identification and lead optimization
• Advancing small molecule, antibody candidates through preclinical studies, SAR, in vitro and in vivo pharmacology
• Identifying and implementing technologies and approaches that will enable the identification of small molecule modulators and antibodies against drug targets with desired activities
• Providing project leadership from target validation to preclinical candidate selection by working and coordinating efforts with multi-disciplinary groups including medicinal chemistry, in vitro/in vivo ADME and in vivo pharmacology

Requirements:

• A broad-based understanding of mammalian cell signal transduction and a detailed knowledge of cutting-edge molecular, biochemical and cellular drug discovery approaches 
• A Ph.D. in a relevant field with 3+ years of relevant post-doctoral work and a demonstrated record of scientific achievement
• Prior experience with muscle biology strongly desired, with specific experience in at least one of the following areas: muscle regeneration models, stems cell approaches, mouse models of neuromuscular and muscular diseases.
• Prior drug discovery and supervisory experience in a biotech or pharma setting is desirable

Send CV/resume as attachment to the email address listed below (please include job code).