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Human Genetics Computational Biologist / Novartis / NIBR - San Diego

Job ID

315769BR

Position Title

Human Genetics Computational Biologist / Novartis / NIBR - San Diego

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4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 22 years of GNF history!

The Genomics Institute for the Novartis Research Foundation (GNF) in San Diego, CA, one of the Novartis Institutes of Biomedical Research (NIBR), is seeking a computational biologist with extensive experience analyzing human genetic data to support the discovery of breakthrough therapies for treating a number of debilitating diseases in General Medical Biology. You will work closely with interdisciplinary drug discovery teams composed of disease area biologists, chemists, translational specialists, as well as geneticists and data scientists at NIBR sites in Cambridge MA and Basel Switzerland, to identify new genetic targets and biomarkers and to stratify patient populations, utilizing both external and internal datasets. The successful candidate will be highly motivated, creative and collaborative, and possess effective communication skills.

Responsibilities will include:

• Providing genetics expertise for target identification using current statistical genetics methods, e.g., GWAS, MR, PRS, and eQTL / pQTL analyses.
• Mining large human Omic datasets for biomarker discovery, patient stratification, and drug reposition / indication expansion.
• Contributing to drug discovery efforts by designing and analyzing transcriptomic, proteomic, or epi-genomic data generation experiments for the determination of compound mechanism of action and pre-clinical biomarker discovery.
• Clearly communicating key findings through interactive data visualizations and presentations.[#video#https://youtu.be/6zHT-WPPFLY{#400,300#}#/video#]

What you will bring to the role:

• Ph.D. in genetics, biostatistics, computational biology, or related field (Expert II DS level), plus >3 years work experience in an industrial or academic setting (Sr. Expert I DS level).
• Experience analyzing and interpreting human genetics data is required.
• Familiarity with the analysis of large biobank data is desired.
• Experience analyzing transcriptomic (e.g., bulk and/or single cell RNAseq), proteomic, and/or epi-genomic (e.g., ATAC-Seq) data is highly desired.
• Significant experience in R or Python and competency working in a Linux/Unix environment is required. Proficiency in other languages, e.g., SQL, java, Matlab is a plus.
• Demonstrated working knowledge and application of data modeling and machine learning/deep learning is a plus.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Division

NIBR

Business Unit

GNF

Location

USA

Site

San Diego, CA

Company/Legal Entity

NIBRI

Functional Area

Data Science

Job Type

Full Time

Employment Type

Regular

Shift Work

No