Principal Scientist, Enzymology / In Vitro Pharmacology - Novartis

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Position Title

Principal Scientist, Enzymology / In Vitro Pharmacology - Novartis

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4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 20 years of GNF history!

The Assay Development/HTS group at GNF is seeking a talented, highly motivated, creative and collaborative Ph.D. level scientist to support the small-molecule drug discovery.

Your responsibilities:

• Lead the in vitro pharmacology efforts to support various small molecule drug discovery projects
• Design and execute relevant biochemical assays to understand inhibitor potency and mechanism of action. Provide data interpretation, insights and recommendations to the team
• Characterize the protein targets and determine the kinetic parameters
• Optimize/miniaturize the assays to enable HTS (high-throughput screening)
• Execute HTS, provide data analysis and interpretation
• Keep up with literature, bring in and evaluate new technologies
• Minimal 50% bench time
• Mentor/manage associates[#video#https://youtu.be/6zHT-WPPFLY{#400,300#}#/video#]

What you will bring to the role:

• PhD degree in enzymology, biochemistry, or related discipline with 2+ years of post-doctoral experience. Prior industrial experience is preferred.
• A strong background in mechanistic enzymology, enzyme kinetics, biochemistry and biochemical assay development
• Good understanding of various assay methods and principles
• Ability to independently design and conduct experiments, and to analyze, interpret and communicate data in project team meetings
• Excellent technical ability at the bench
• Strong leadership, management, communication, and interpersonal skills.

Highly desirable:

• Experience in cellular assay development and knowledge of signaling pathways.
• Prior experience in small-molecule screening including familiarity with automation.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.



Business Unit





San Diego, CA

Company/Legal Entity


Functional Area

Research & Development

Job Type

Full Time

Employment Type


Shift Work