Senior Scientist Protein Sciences Novartis / NIBR / GNF / San Diego

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Position Title

Senior Scientist Protein Sciences Novartis / NIBR / GNF / San Diego

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4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 21 years of GNF history!

The Protein Sciences Department is looking for a highly motivated Senior Scientist to operate a 96-sample high-throughput bacterial fermentation system. The candidate will be part of a multidisciplinary team that supports early stage small molecule and biologic drug discovery programs by performing bacterial and mammalian protein expression, purification and subsequent physicochemical characterization.

Your responsibilities:

• Setup, operation, optimization and maintenance of fermenter system
• Adapt shaker flask expression protocols to high density fermentation
• Primary protein purification
• Troubleshoot production runs
• Work with on-site engineering group to develop new workflows and instrumentation
• Support the collection of analytical data (anSEC, CE, and LCMS)
• Present scientific and technical work
• Write technical reports and SOPs
• Interact with various project teams across both GNF and the larger Novartis organization [#video#https://youtu.be/6zHT-WPPFLY{#400,300#}#/video#]

What you will bring to the role:

• BS/MS in biochemistry or related field
• Expertise in E. coli protein expression is required, ideally as part of a high-throughput protein expression platform/pipeline, although all motivated individuals are invited to apply.
• Experience with other expression systems such as yeast, HEK, CHO or insect is advantageousA practical understanding of protein purification techniques and instrumentation (gravity, FPLC, HPLC, NTA, SEC, RP etc.)
• Experience with molecular biology techniques such DNA isolation, transformation, etc.
• Familiarity/knowledge of biophysical methods (SPR, light scattering, ITC, DSC, etc) and laboratory automation is high desirable
• High degree of self-motivation and attention to detail and strong organizational and time management skills
• Desire to learn/operate across numerous functions (expression, purification, analytics and biophysics)

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.



Business Unit





San Diego, CA

Company/Legal Entity


Functional Area

Research & Development

Job Type

Full Time

Employment Type


Shift Work