X

Sr Principal Scientist/Associate Director DMPK Novartis GNF San Diego

Job ID

321645BR

Position Title

Sr Principal Scientist/Associate Director DMPK Novartis GNF San Diego

Apply to Job

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 20 years of GNF history! For over 21 years, the Genomics Institute of the Novartis Research Foundation (GNF) has been doing cutting-edge innovative drug discovery for Novartis global research organization, the Novartis Institute for BioMedical Research, Inc (NIBRI).

We are seeking a Senior Principal Scientist (Associate Director) for the Drug Metabolism and Pharmacokinetics (DMPK) organization at the Genomics Institute of Novartis Research Organization (GNF) to drive the discovery and development of novel therapeutics. The successful candidate will provide strategic and broad team leadership on drug discovery projects, collaborating with other disciplines to define the team’s objectives and to guide the project to critical decision points during its progression towards identification of a clinical candidate. He/she will support preclinical drug discovery and development with expertise in the pharmacokinetics and pharmacodynamics (PK/PD), absorption, distribution, metabolism and excretion (ADME), and will drive talent development by mentoring in these areas as well.

Your responsibilities:

• Support DMPK of molecules from a variety of disease areas including oncology, metabolic diseases and regenerative medicine.
• Support the efficient application and integration of PK and ADME studies to advance lead optimization and clinical candidate selection
• Provide in-depth knowledge of drug-drug interactions, biotransformation, bioanalytical and pharmacokinetic/pharmacodynamic (PK/PD)-modeling sciences.
• Represent the DMPK discipline on global cross-functional project teams while driving the design, execution and analysis of DMPK and PK/PD.
• Support DMPK of a variety of modalities including small molecules, conjugates, therapeutic proteins and antibodies that are hits from phenotypic or target based screens in early discovery.
• Serve as a primary source of scientific expertise for the design, analysis, reporting and presentation of pharmacokinetic and pharmacodynamic modeling and safety studies.
• Bring innovative ideas and approaches which inform and influence the overall drug discovery and development process.
• Collaborate with global PK Sciences to ensure an aligned position on human PK/PD projections as candidates transition into the clinic.
• Provides leadership to ensure scientific integrity of documents related to preclinical and clinical drug development process including Investigator Brochures, INDs, protocols and final study reports.
• Support DMPK components of preclinical and clinical study protocol designs, preclinical and clinical study reports.[#video#https://youtu.be/6zHT-WPPFLY{#400,300#}#/video#]

What you will bring to the role:

• Ph.D. in pharmaceutical sciences, DMPK or related disciplines with thorough knowledge of clinical pharmacology, absorption, distribution, drug metabolism, pharmacokinetics and PK/PD modeling
• Broad knowledge of preclinical and early clinical drug discovery, preferably in both low molecular weight and in biotherapeutics
• Minimum 10 years of pharmaceutical industry experience including preclinical DMPK, PK/PD modeling, drug development , protocol/IB preparation support, regulatory interactions and submissions
• Demonstrated leadership and project management skills
• Familiarity and hands on experience with Phoenix WinNonlin and/or NONMEM, GastroPlus etc. is a plus
• Excellent communication and interpersonal skills and the ability to facilitate constructive, expedient problem solving.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.

The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Division

NIBR

Business Unit

GNF

Location

USA

Site

San Diego, CA

Company/Legal Entity

NIBRI

Functional Area

Research & Development

Job Type

Full Time

Employment Type

Regular

Shift Work

No