Principal Scientist II

Job ID


Position Title

Principal Scientist II

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The GNF Structure Based Discovery group is seeking a highly motivated Investigator level Structural Biologist with a passion for applying X-ray Crystallography and/or Cryo-EM to small molecule and biotherapeutic drug discovery.

The successful candidate will work closely with interdisciplinary teams of GNF/NIBR scientists to enable innovative structure based drug design. The chosen applicant will play an integral role in defining the direction and science of structural biology and structure based design within the organization.

Responsibilities will include, but not be limited to:

•Provide structural biology support to expedite the development of both small-molecule and protein-based biotherapeutics.
•Work with medicinal chemists and Computer Aided Drug Designers to improve the properties of candidate small molecules.
•Utilize structural biology, modelling and protein engineering techniques to improve and enhance the properties of next-generation biologics.[#video#https://www.youtube.com/watch?v=Z9hdwdC8klc{#400,300#}#/video#]



Business Unit





San Diego, CA

Company/Legal Entity

Functional Area

Research & Development

Job Type

Full Time

Employment Type


Shift Work

•PhD in macromolecular crystallography, biochemistry, biophysics or related field with a minimum of 2 years industrial or postdoctoral experience preferred.
•Successful track record of scientific accomplishments in the field of protein structure.
•Experience in the gene to structure pipeline, including construct design, standard molecular biology techniques, recombinant protein expression and purification.
•Experience with protein modelling and computational design.
•Familiarity with biophysical methods used for protein characterization including DSF, SEC-MALS, LCMS and SPR.
•Expertise in X-ray crystallography, some familiarity with Cryo-EM techniques is preferred.
•Ability to work in a multidisciplinary team environment, self-motivated, detail oriented and organized.
•Strong oral and written communication skills.

Why consider Novartis?
769 million. That’s how many lives our products touched in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.
Imagine what you could do at Novartis!

Commitment to Diversity & Inclusion:
Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.