(Sr.) Principal Scientist

Job ID


Position Title

(Sr.) Principal Scientist

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4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 20 years of GNF history! For over 21 years, the Genomics Institute of the Novartis Research Foundation (GNF) has been doing cutting-edge innovative drug discovery for Novartis global research organization, the Novartis Institute for BioMedical Research (NIBR).

We are seeking a chemist with strong background in RNA synthesis and delivery who is flexible, inclusive and highly motivated with an enterprise-thinking mindset. The successful candidate will collaborate closely with multi-disciplinary teams within the organization. This is a chance to work on innovative drug discovery strategies with the potential to be clinically transformative.

Your responsibilities:

-Collaborate closely with colleagues to advance innovative RNA therapeutics to unmet medical needs in various disease areas
-Develop therapeutic RNAs and their delivery systems including siRNAs/ASOs, linkers and vehicles to achieve improved systemic targeted delivery of therapeutic RNAs

What you will bring to the role:

-Strong background in Organic Chemistry or closely related field and working experience in the relevant industry or academia with a proven track record of accomplishments
-Expertise in chemical synthesis and derivatization of oligonucleotides, in particular the-state-of-the-art siRNAs and ASOs
-Strong expertise in systemic RNA delivery
-Excellent hands-on ability in custom linkers, and derivatization of RNAs
-Ability to champion and advance creative concepts in a team setting
-Innovative, independent and detail-oriented problem solving skills
-Ability to handle multiple tasks effectively but to focus as needed
-Engagement with multidisciplinary project teams to design, execute, and interpret experiments
-Ability to manage complexity and ambiguity in a highly matrixed work environment
-Effective communication skills, both verbal and written
-Productive relationships with collaborators and champion Novartis values and behaviors




Business Unit





San Diego, CA

Company/Legal Entity

Functional Area

Research & Development

Job Type

Full Time

Employment Type


Shift Work

What you will bring to the role:

Relevant experience and desirables:

-Design, synthesis and application of small-molecule RNA conjugates, antibody RNA conjugates, and other targeted RNA delivery systems
-Understanding of ADMETox properties and PK-PD relationship
-Understanding of basic bioconjugation and, protein engineering concepts
-Ability to work in close collaboration with ADME, PK, and pharmacology colleagues
-Management of outsourcing RNA synthesis

We are Novartis. Join us and help us reimagine medicine.

Commitment to Diversity & Inclusion:
Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration, and empowers our people to unleash their full potential.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis

Network here: https://talentnetwork.novartis.com/network