Principal Scientist, AAV Virology Novartis NIBR San Diego

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Position Title

Principal Scientist, AAV Virology Novartis NIBR San Diego

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4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 20 years of GNF history! For over 21 years, the Genomics Institute of the Novartis Research Foundation (GNF) has been doing cutting-edge innovative drug discovery for Novartis global research organization, the Novartis Institute for BioMedical Research (NIBR).

Your responsibilities:

• Lead and participate in research efforts to develop safer and more potent AAV vectors in areas including, but not limited to, AAV capsid evolution and engineering, reduction of immune response, circuit engineering, and strategies for high throughput optimization of AAVs.
• Oversee & lead AAV capsid and vector engineering programs and enable translation from in vitro/in vivo POC studies to therapeutic disease programs for preclinical development.
• Initiate, lead and contribute to interdisciplinary research programs in a highly collaborative and matrixed manner across internal groups and with external partners.
• Contributes to maintaining a safe laboratory environment and quality work practices.
• Other related duties as assigned.




Business Unit





San Diego, CA

Company/Legal Entity

Functional Area

Research & Development

Job Type

Full Time

Employment Type


Shift Work

What you will bring to the role:

• Bachelor’s degree with 8 years relevant experience, Master's with 6 years relevant experience or PHD with 4 years relevant experience.
• Advanced training in AAV virology, synthetic biology, gene therapy, bioinformatics, molecular/cell biology, or related scientific field.
• Demonstrated expertise in AAV capsid evolution and optimization, AAV genome engineering, genomics & epigenomics fields and nucleic acid technologies and tools, including library generation.
• Process development for AAV production is highly desired.
• Experience in Adenovirus cloning, production, and purification to be considered as a substitute for AAV.
• Ability to work collaboratively across a dynamic and collaborative scientific and development environment.
• Adaptability to emerging project/group needs, excellent communication skills, both written and verbal, and strong interpersonal skills.
• Strong publication, patent and external presentation record is preferred.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.