Postdoctoral Associate, Cancer Therapeutics Novartis NIBR San Diego

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Postdoctoral Associate, Cancer Therapeutics Novartis NIBR San Diego

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6,000 people dedicated to discovery - 6 research campuses across the globe. At Novartis Institutes for BioMedical Research (NIBR), NIBR Informatics serves the global NIBR research community to provide them with the best of breed, leading edge informatics platforms as well as in-depth data analysis services. The members in this group have a chance to participate in the groundbreaking medical research activities that redefine the grammar for medicine in the post-genome era.

The Cancer Therapeutics department at the Novartis Institutes for Biomedical Research (NIBR) in San Diego/GNF has an opening for a postdoctoral associate. NIBR is a world class research organization that pioneers new drug discovery technologies leading to an innovative portfolio of several dozen preclinical projects. NIBR San Diego/GNF offers a special environment in which to conduct research, in which fundamental science questions are explored using industry resources and close collaboration with experts in cell biology, pharmacology, chemistry, proteomics, and genomics. [#video#https://www.youtube.com/watch?v=IXumFqhsHG8{#400,300#}#/video#]



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San Diego, CA

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Research & Development

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Full Time

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Mutation in genes in the MAPK pathway drives oncogenesis in several solid tumor types. Targeted therapies that inhibit these critical signaling nodes have led to breakthrough therapies, most recently in KRAS G12C mutant cancers. Clinical success for direct targeting of KRAS G12C has led to intense interest in finding new small molecules that bind to other KRAS mutants. However, it is increasingly clear that KRAS mutants differ in downstream signaling and selected mutant alleles are found in tissue specific contexts. The postdoctoral associate who joins our group will study small molecule interactions with KRAS mutants using biochemical, structural and biophysical techniques. These studies will inform cell biological studies looking at small molecule effects on cancer cell signaling and survival. The postdoc will also work closely with proteomics specialists who are discovering novel PPIs in the RAS pathway; these findings will lead to design of combination studies which will be tested both in vitro and in vivo. Candidates for this position should have a Ph.D. in biochemistry, cancer biology, chemical biology or related field; a strong publication record; passion for studying cancer biology at the molecular level; and excellent communication and collaboration skills.

Why consider Novartis?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

We are Novartis. Join us and help us reimagine medicine.