GNF utilizes industrial robots to conduct high-throughput screening – a central component in the organization’s multifaceted drug discovery process. Researchers tests thousands, or even millions, of agents from an enormous compound library to find the exact small molecule(s) that will best target a specific biological pathway and/or change a cellular phenotype.
Because GNF is keenly interested in developing first-in-class treatments to meet the most challenging medical needs, the success of this exploration process often hinges on precision chemistry.
Medicinal and pharmaceutical chemists work closely with biologists, engineers and others to optimize small molecules and develop antibody-drug conjugates to advance promising compounds into the drug development process.
GNF has a fully integrated model that brings together all of the functions necessary for drug discovery under one umbrella—it’s an ambitious, exciting, and unique research environment.
GNF chemists are constantly looking for better ways to increase a potential drug’s specificity, optimizing molecules to perturb diseased cells but leave healthy ones alone. The hope for molecularly targeted drug discovery is to maximize efficiency and minimize side effects. Other efforts focus on drug pharmacokinetics, toxicology and compound analysis and purification.
This collaborative environment has generated a wide range of innovative ways to help researchers better recapitulate human biology during high-throughput screening. For example, the chemistry and bioengineering groups have worked closely to develop polymer-based tools to enhance 3D screening, co-culture systems to examine multiple cells at once making it possible to study biological systems, like cartilage. While the department’s ever more advanced chemical technologies—such as photochemistry and flow chemistry—open doors to new chemical reactions.
GNF chemists play a central role in the organization’s drug discovery success. Having the freedom to pursue high-risk, high-reward research unlocks new level of innovation, enabling scientists to answer challenging biological questions and develop new medicines to alleviate suffering and improve quality of life.