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Selected Publications

Selected Publications

2020

Acoustic Droplet Ejection and Open Port Interface for Rapid Analysis of Metabolic Stability Assays.
Hollenbeck T, Thibodeaux S, White P, Westling L, Chong A, Isbell J.
Journal of pharmaceutical sciences. 2020 Jul; ()

Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Alper PB, Deane J, Betschart C, Buffet D, Collignon Zipfel G, Gordon P, Hampton J, Hawtin S, Ibanez M, Jiang T, Junt T, Knoepfel T, Liu B, Maginnis J, McKeever U, Michellys PY, Mutnick D, Nayak B, Niwa S, Richmond W, Rush JS, Syka P, Zhang Y, Zhu X.
Bioorganic & medicinal chemistry letters. 2020 Sep; 30(17): 127366.

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.
Baht GS, Bareja A, Lee DE, Rao RR, Huang R, Huebner JL, Bartlett DB, Hart CR, Gibson JR, Lanza IR, Kraus VB, Gregory SG, Spiegelman BM, White JP.
Nature metabolism. 2020 Mar; 2(3): 278-289.

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus BS, Kreishman-Deitrick M, Bursulaya B, Lai Y, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis L, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz P, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne R, Supek F, Weismann C, Molteni V.
Journal of medicinal chemistry. 2020 Jul; ()

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.
Saldivia M, Fang E, Ma X, Myburgh E, Carnielli JBT, Bower-Lepts C, Brown E, Ritchie R, Lakshminarayana SB, Chen YL, Patra D, Ornelas E, Koh HXY, Williams SL, Supek F, Paape D, McCulloch R, Kaiser M, Barrett MP, Jiricek J, Diagana TT, Mottram JC, Rao SPS.
Nature microbiology. 2020 Jul; ()

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.
Fu Y, Estoppey D, Roggo S, Pistorius D, Fuchs F, Studer C, Ibrahim AS, Aust T, Grandjean F, Mihalic M, Memmert K, Prindle V, Richard E, Riedl R, Schuierer S, Weber E, Hunziker J, Petersen F, Tao J, Hoepfner D.
Nature communications. 2020 Jul; 11(1): 3387.

A cell-level quality control workflow for high-throughput image analysis.
Qiu M, Zhou B, Lo F, Cook S, Chyba J, Quackenbush D, Matzen J, Li Z, Mak PA, Chen K, Zhou Y.
BMC bioinformatics. 2020 Jul; 21(1): 280.

A Dual Inhibitor of DYRK1A and GSK3? for ?-Cell Proliferation: Aminopyrazine Derivative GNF4877.
Liu YA, Jin Q, Ding Q, Hao X, Mo T, Yan S, Zou Y, Huang Z, Zhang X, Gao W, Wu TY, Li C, Bursalaya B, Di Donato M, Zhang YQ, Deaton L, Shen W, Taylor B, Kamireddy A, Harb G, Li J, Jia Y, Schumacher AM, Laffitte B, Glynne R, Pan S, McNamara P, Molteni V, Loren J.
ChemMedChem. 2020 Jul; ()

Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.
Gudmundsdottir V, Zaghlool SB, Emilsson V, Aspelund T, Ilkov M, Gudmundsson EF, Jonsson SM, Zilhão NR, Lamb JR, Suhre K, Jennings LL, Gudnason V.
Diabetes. 2020 Aug; 69(8): 1843-1853.

Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
Mathison CJN, Chianelli D, Rucker PV, Nelson J, Roland J, Huang Z, Yang Y, Jiang J, Xie YF, Epple R, Bursulaya B, Lee C, Gao MY, Shaffer J, Briones S, Sarkisova Y, Galkin A, Li L, Li N, Li C, Hua S, Kasibhatla S, Kinyamu-Akunda J, Kikkawa R, Molteni V, Tellew JE.
ACS medicinal chemistry letters. 2020 Apr; 11(4): 558-565.

Opinion on Current Use of Non-Blinded Versus Blinded Histopathologic Evaluation in Animal Toxicity Studies.
Bolon B, Caverly Rae JM, Colman K, Francke S, Jensen K, Keane K, McInnes EF, Nakano-Ito K, Perry R, Polack E, Regan KS, Romeike A, Young JK, Galbreath EJ.
Toxicologic pathology. 2020 Jun; 48(4): 549-559.

Enhanced in-Source Fragmentation Annotation Enables Novel Data Independent Acquisition and Autonomous METLIN Molecular Identification.
Xue J, Domingo-Almenara X, Guijas C, Palermo A, Rinschen MM, Isbell J, Benton HP, Siuzdak G.
Analytical chemistry. 2020 Apr; 92(8): 6051-6059.

Identification of a small molecule that stimulates human ?-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
Hohmeier HE, Zhang L, Taylor B, Stephens S, Lu D, McNamara P, Laffitte B, Newgard CB.
PloS one. 2020; 15(3)

Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C–CN Bond Cleavage and Cyano Transfer
Chen H, Sun S, Liu YA, Liao X.
ACS Catal. 2020 Mar; 10(2): 1397-1405.
 

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis.
Rao SPS, Lakshminarayana SB, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Mäser P, Mottram JC, Barrett MP, Diagana TT.
Tropical medicine and infectious disease. 2020 Feb; 5(1)

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
Liu YA, Jin Q, Zou Y, Ding Q, Yan S, Wang Z, Hao X, Nguyen B, Zhang X, Pan J, Mo T, Jacobsen K, Lam T, Wu TY, Petrassi HM, Bursulaya B, DiDonato M, Gordon WP, Liu B, Baaten J, Hill R, Nguyen-Tran V, Qiu M, Zhang YQ, Kamireddy A, Espinola S, Deaton L, Ha S, Harb G, Jia Y, Li J, Shen W, Schumacher AM, Colman K, Glynne R, Pan S, McNamara P, Laffitte B, Meeusen S, Molteni V, Loren J.
Journal of medicinal chemistry. 2020 Mar; 63(6): 2958-2973.

An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis.
Ruff Y, Martinez R, Pellé X, Nimsgern P, Fille P, Ratnikov M, Berst F.
ACS combinatorial science. 2020 Mar; 22(3): 120-128.

Importance of model size in quantum mechanical studies of DNA intercalation.
Harding DP, Kingsley LJ, Spraggon G, Wheeler SE.
Journal of computational chemistry. 2020 Feb;

A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies.
Phillips JA, Grandhi TSP, Davis M, Gautier JC, Hariparsad N, Keller D, Sura R, Van Vleet TR.
Lab on a chip. 2020 Feb; 20(3): 468-476.

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.
Nature chemical biology. 2020 Jan;

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M, Schlama T, Liu Y, Chu A, Schmeits J, Huang DJ, Hill R, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Liu B, Richmond W, Sancho-Martinez I, Phimister A, Seidel HM, Badman MK, Joseph SB, Laffitte B, Molteni V.
Journal of medicinal chemistry. 2020 Feb;

Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
McAllister CS, Ansaldi D, Growcott EJ, Zhong Y, Quackenbush D, Wolff KC, Chen Z, Tanaseichuk O, Lelais G, Barnes SW, Federe GC, Luna F, Walker JR, Zhou Y, Kuhen KL.
Virology. 2020 Jan; 540: 195-206.

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.
Nature chemical biology. 2020 Jan; 16(1): 15-23.

Tau overexpression exacerbates neuropathology after repeated mild head impacts in male mice.
Cheng H, Deaton LM, Qiu M, Ha S, Pacoma R, Lao J, Tolley V, Moran R, Keeton A, Lamb JR, Fathman J, Walker JR, Schumacher AM.
Neurobiology of disease. 2020 Feb; 134: 104683.

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease.
Thangavelu G, Du J, Paz KG, Loschi M, Zaiken MC, Flynn R, Taylor PA, Kirchmeier AK, Panoskaltsis-Mortari A, Luznik L, MacDonald KP, Hill GR, Maillard I, Munn DH, Serody JS, Murphy WJ, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Dahlberg C, Miller AT, Blazar BR.
Blood. 2020 Jan; 135(1): 28-40.

 

2019

Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Jones AK, Caughlan RE, Woods AL, Uehara K, Xie L, Barnes SW, Walker JR, Thompson KV, Ranjitkar S, Lee PS, Dean CR.
Antimicrobial agents and chemotherapy. 2019 Dec; 64(1)

Low-Dose Subcutaneous Anti-CD20 Treatment Depletes Disease Relevant B Cell Subsets and Attenuates Neuroinflammation.
Huck C, Leppert D, Wegert V, Schmid C, Dunn R, Weckbecker G, Smith PA.
Journal of neuroimmune pharmacology. 2019 Dec; 14(4): 709-719.

Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.
Hernandez ED, Zheng L, Kim Y, Fang B, Liu B, Valdez RA, Dietrich WF, Rucker PV, Chianelli D, Schmeits J, Bao D, Zoll J, Dubois C, Federe GC, Chen L, Joseph SB, Klickstein LB, Walker J, Molteni V, McNamara P, Meeusen S, Tully DC, Badman MK, Xu J, Laffitte B.
Hepatology communications. 2019 Aug; 3(8): 1085-1097.

Structures of single-layer ?-sheet proteins evolved from ?-hairpin repeats.
Xu Q, Biancalana M, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA.
Protein science. 2019 Sep; 28(9): 1676-1689.

Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
Velcicky J, Mathison CJN, Nikulin V, Pflieger D, Epple R, Azimioara M, Cow C, Michellys PY, Rigollier P, Beisner DR, Bodendorf U, Guerini D, Liu B, Wen B, Zaharevitz S, Brandl T.
ACS medicinal chemistry letters. 2019 Jun; 10(6): 887-892.

Tropifexor Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
Hernandez ED, Zheng L, Kim Y, Fang B, Liu B, Valdez RA, Dietrich WF, Rucker PV, Chianelli D, Schmeits J, Bao D, Zoll J, Dubois C, Federe GC, Chen L, Joseph SB, Klickstein LB, Walker J, Molteni V, McNamara P, Meeusen S, Tully DC, Badman MK, Xu J, Laffitte B.
Hepatology Comm. 2019 May; 3(8): 1085-1097.

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity.
Ahmed SM, Ramani PD, Wong SQR, Zhao X, Ivanyi-Nagy R, Leong TC, Chua C, Li Z, Hentze H, Tan IB, Yan J, DasGupta R, Dröge P.
PloS one. 2019; 14(5)

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Sellers WR, Lees E, Shao W, Dillon MP, Stuart DD.
Journal of medicinal chemistry. 2019 May;

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb.
Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S.
Analytical chemistry. 2019 Jun; 91(11): 7336-7345.

Defects in Efflux (oprM), ?-Lactamase (ampC), and Lipopolysaccharide Transport (lptE) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61.
Shen X, Johnson NV, Kreamer NNK, Barnes SW, Walker JR, Woods AL, Six DA, Dean CR.
Antimicrobial agents and chemotherapy. 2019 Jul; 63(7)

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK.
Nature communications. 2019 Apr; 10(1): 1523.

Development of a virtual reality platform for effective communication of structural data in drug discovery.
Kingsley LJ, Brunet V, Lelais G, McCloskey S, Milliken K, Leija E, Fuhs SR, Wang K, Zhou E, Spraggon G.
Journal of molecular graphics & modelling. 2019 Jun; 89: 234-241.

Joints in the appendicular skeleton: Developmental mechanisms and evolutionary influences.
Rux D, Decker RS, Koyama E, Pacifici M.
Curr Top Dev Biol. 2019 ; 133: 119-151.

Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes
Huang Z, Tremblay MS, Wu TY, Ding Q, Hao X, Baaten J, Hill R, Liu B, Meeusem S, Zou Y, Yan S, Jia Y, Nguyen-Tran V, Shen W, Bhat G, Glynne R, Laffitte B, Li J, Molteni V, Liu YA.
ACS Omega. 2019 Feb; 4(2): 3571-3581.

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.
Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL.
Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar; 116(13): 6435-6440.

Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
Li Z, Yang F, Xuan Y, Xi R, Zhao R.
Scientific reports. 2019 Mar; 9(1): 3226.

Identification of a Xist silencing domain by Tiling CRISPR.
Wang Y, Zhong Y, Zhou Y, Tanaseichuk O, Li Z, Zhao JC.
Scientific reports. 2019 Feb; 9(1): 2408.

Discovering highly selective and diverse PPAR-delta agonists by ligand based machine learning and structural modeling.
Da'adoosh B, Marcus D, Rayan A, King F, Che J, Goldblum A.
Scientific reports. 2019 Jan; 9(1): 1106.

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.
Cao J, Zhu Z, Wang H, Nichols TC, Lui GYL, Deng S, Rejto PA, VanArsdale T, Hardwick JS, Weinrich SL, Wei P.
Oncogene. 2019 May; 38(21): 4125-4141.

One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling.
Koyanagi T, Herath A, Chong A, Ratnikov M, Valiere A, Chang J, Molteni V, Loren J.
Organic letters. 2019 Feb; 21(3): 816-820.

STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice.
Liu X, Wang H, Jiang Y, Zheng Q, Petrus M, Zhang M, Zheng S, Schmedt C, Dong X, Xiao B.
Cell research. 2019 Feb; 29(2): 95-109.

8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity.
Leven M, Held J, Duffy S, Alves Avelar LA, Meister S, Delves M, Plouffe D, Kuna K, Tschan S, Avery VM, Winzeler EA, Mordmüller B, Kurz T.
ChemMedChem. 2019 Feb; 14(4): 501-511.

Enabling drug discovery and development through single-cell imaging.
Pomerantz AK, Sari-Sarraf F, Grove KJ, Pedro L, Rudewicz PJ, Fathman JW, Krucker T.
Expert opinion on drug discovery. 2019 Feb; 14(2): 115-125.

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA.
Nature. 2019 Jan; 565(7738)

Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action.
Wang AC, Pham HT, Lipps JM, Brittain SM, Harrington E, Wang Y, King FJ, Russ C, Pan X, Hoepfner D, Tallarico J, Feng Y, Jain RK, Schirle M, Thomas JR.
ACS chemical biology. 2019 Jan; 14(1): 20-26.

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of ?-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.
Ranjitkar S, Jones AK, Mostafavi M, Zwirko Z, Iartchouk O, Barnes SW, Walker JR, Willis TW, Lee PS, Dean CR.
Antimicrobial agents and chemotherapy. 2019 Feb; 63(2)

Plasma Protein Binding of Highly Bound Drugs Determined With Equilibrium Gel Filtration of Nonradiolabeled Compounds and LC-MS/MS Detection.
Isbell J, Yuan D, Torrao L, Gatlik E, Hoffmann L, Wipfli P.
Journal of pharmaceutical sciences. 2019 Feb; 108(2): 1053-1060.

 

2018

Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.
Ting PY, Parker AE, Lee JS, Trussell C, Sharif O, Luna F, Federe G, Barnes SW, Walker JR, Vance J, Gao MY, Klock HE, Clarkson S, Russ C, Miraglia LJ, Cooke MP, Boitano AE, McNamara P, Lamb J, Schmedt C, Snead JL.
Nat Methods. 2018 Oct;

Co-regulatory networks of human serum proteins link genetics to disease.
Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Aspelund T, Shu L, Trifonov V, Sigurdsson S, Manolescu A, Zhu J, Olafsson Ö, Jakobsdottir J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Orth AP, Jennings LL, Gudnason V.
Science. 2018 Aug; 361(6404): 769-773. 

2000-2017

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
Tully DC, Rucker PV, Chianelli D, Williams J, Vidal A, Alper PB, Mutnick D, Bursulaya B, Schmeits J, Wu X, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Seidel HM, Molteni V, Liu B, Phimister A, Joseph SB, Laffitte B.
J Med Chem. 2017 Dec; 60(24): 9960-9973.

The microprotein Minion controls cell fusion and muscle formation.
Zhang Q, Vashisht AA, O'Rourke J, Corbel SY, Moran R, Romero A, Miraglia L, Zhang J, Durrant E, Schmedt C, Sampath SC, Sampath SC.
Nat Commun. 2017 Jun; 8: 15664.

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H, Palakurthi S, Jang J, Lelais G, DiDonato M, Bursulaya B, Michellys PY, Epple R, Marsilje TH, McNeill M, Lu W, Harris J, Bender S, Wong KK, Jänne PA, Eck MJ.
Nature. 2016 May; 534(7605): 129-32.

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M, Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F.
Nature. 2016 Sep; 537(7619): 229-233.

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F.
PLoS Pathog. 2015 Jul; 11(7)

Inhibition of DYRK1A and GSK3B induces human ß-cell proliferation.
Shen W, Taylor B, Jin Q, Nguyen-Tran V, Meeusen S, Zhang YQ, Kamireddy A, Swafford A, Powers AF, Walker J, Lamb J, Bursalaya B, DiDonato M, Harb G, Qiu M, Filippi CM, Deaton L,
Turk CN, Suarez-Pinzon WL, Liu Y, Hao X, Mo T, Yan S, Li J, Herman AE, Hering BJ, Wu T, Martin Seidel H, McNamara P, Glynne R, Laffitte B.
Nat Commun. 2015 Oct; 6: 8372.

Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.(link is external) 
Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, Batalov S, Harris JL, Liu J. 
BMC Cancer. 2014 Dec; 14: 944.

Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis.(link is external)
Nagle AS, Khare S, Kumar AB, Supek F, Buchynskyy A, Mathison CJ, Chennamaneni NK, Pendem N, Buckner FS, Gelb MH, Molteni V. 
Chem Rev. 2014 Nov

Targeting Plasmodium PI(4)K to eliminate malaria. 
McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. 
Nature. 2013 Dec; 504(7479): 248-53.  

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. 
Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P, Sellers WR, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL. 
Proc Natl Acad Sci U S A. 2013 Dec; 110(50): 20224-9.  

A stem cell-based approach to cartilage repair. 
Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG. 
Science. 2012 May; 336(6082): 717-21.  

Site-specific protein modifications through pyrroline-carboxy-lysine residues. 
Ou W, Uno T, Chiu HP, Grünewald J, Cellitti SE, Crossgrove T, Hao X, Fan Q, Quinn LL, Patterson P, Okach L, Jones DH, Lesley SA, Brock A, Geierstanger BH. 
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Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. 
Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. 
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Parallel methods for expression and purification. 
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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. 
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Essential role of stromally induced hedgehog signaling in B-cell malignancies. 
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M. 
Nat Med. 2007 Aug; 13(8): 944-51.  

The nuclear receptor LXR is a glucose sensor. 
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E. 
Nature. 2007 Jan; 445(7124): 219-23.  

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. 
Galkin AV, Melnick JS, Kim S, Hood TL, Li N, Li L, Xia G, Steensma R, Chopiuk G, Jiang J, Wan Y, Ding P, Liu Y, Sun F, Schultz PG, Gray NS, Warmuth M. 
Proc Natl Acad Sci U S A. 2007 Jan; 104(1): 270-5.  

An efficient rapid system for profiling the cellular activities of molecular libraries. 
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Illumination of the melanopsin signaling pathway. 
Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T. 
Science. 2005 Jan; 307(5709): 600-4.  

A gene atlas of the mouse and human protein-encoding transcriptomes. 
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. 
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Genome-scale functional profiling of the mammalian AP-1 signaling pathway. 
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Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. 
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Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. 
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A heat-sensitive TRP channel expressed in keratinocytes. 
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Science. 2002 Jun; 296(5575): 2046-9.  

Substrate specificity of the human proteasome. 
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Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. 
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Genomics, gene expression and DNA arrays. 
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Nature. 2000 Jun; 405(6788): 827-36.