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Selected Publications

Selected Publications

2020

Importance of model size in quantum mechanical studies of DNA intercalation.
Harding DP, Kingsley LJ, Spraggon G, Wheeler SE.
Journal of computational chemistry. 2020 Feb;

A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies.
Phillips JA, Grandhi TSP, Davis M, Gautier JC, Hariparsad N, Keller D, Sura R, Van Vleet TR.
Lab on a chip. 2020 Feb; 20(3): 468-476.

Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.
Nature chemical biology. 2020 Jan;

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Chianelli D, Rucker PV, Roland J, Tully DC, Nelson J, Liu X, Bursulaya B, Hernandez ED, Wu J, Prashad M, Schlama T, Liu Y, Chu A, Schmeits J, Huang DJ, Hill R, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Liu B, Richmond W, Sancho-Martinez I, Phimister A, Seidel HM, Badman MK, Joseph SB, Laffitte B, Molteni V.
Journal of medicinal chemistry. 2020 Feb;

Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling.
McAllister CS, Ansaldi D, Growcott EJ, Zhong Y, Quackenbush D, Wolff KC, Chen Z, Tanaseichuk O, Lelais G, Barnes SW, Federe GC, Luna F, Walker JR, Zhou Y, Kuhen KL.
Virology. 2020 Jan; 540: 195-206.

Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J.
Nature chemical biology. 2020 Jan; 16(1): 15-23.

Tau overexpression exacerbates neuropathology after repeated mild head impacts in male mice.
Cheng H, Deaton LM, Qiu M, Ha S, Pacoma R, Lao J, Tolley V, Moran R, Keeton A, Lamb JR, Fathman J, Walker JR, Schumacher AM.
Neurobiology of disease. 2020 Feb; 134: 104683.

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease.
Thangavelu G, Du J, Paz KG, Loschi M, Zaiken MC, Flynn R, Taylor PA, Kirchmeier AK, Panoskaltsis-Mortari A, Luznik L, MacDonald KP, Hill GR, Maillard I, Munn DH, Serody JS, Murphy WJ, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Dahlberg C, Miller AT, Blazar BR.
Blood. 2020 Jan; 135(1): 28-40.

 

2019

Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms.
Jones AK, Caughlan RE, Woods AL, Uehara K, Xie L, Barnes SW, Walker JR, Thompson KV, Ranjitkar S, Lee PS, Dean CR.
Antimicrobial agents and chemotherapy. 2019 Dec; 64(1)

Low-Dose Subcutaneous Anti-CD20 Treatment Depletes Disease Relevant B Cell Subsets and Attenuates Neuroinflammation.
Huck C, Leppert D, Wegert V, Schmid C, Dunn R, Weckbecker G, Smith PA.
Journal of neuroimmune pharmacology. 2019 Dec; 14(4): 709-719.

Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.
Hernandez ED, Zheng L, Kim Y, Fang B, Liu B, Valdez RA, Dietrich WF, Rucker PV, Chianelli D, Schmeits J, Bao D, Zoll J, Dubois C, Federe GC, Chen L, Joseph SB, Klickstein LB, Walker J, Molteni V, McNamara P, Meeusen S, Tully DC, Badman MK, Xu J, Laffitte B.
Hepatology communications. 2019 Aug; 3(8): 1085-1097.

Structures of single-layer ?-sheet proteins evolved from ?-hairpin repeats.
Xu Q, Biancalana M, Grant JC, Chiu HJ, Jaroszewski L, Knuth MW, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA.
Protein science. 2019 Sep; 28(9): 1676-1689.

Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
Velcicky J, Mathison CJN, Nikulin V, Pflieger D, Epple R, Azimioara M, Cow C, Michellys PY, Rigollier P, Beisner DR, Bodendorf U, Guerini D, Liu B, Wen B, Zaharevitz S, Brandl T.
ACS medicinal chemistry letters. 2019 Jun; 10(6): 887-892.

Tropifexor Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents
Hernandez ED, Zheng L, Kim Y, Fang B, Liu B, Valdez RA, Dietrich WF, Rucker PV, Chianelli D, Schmeits J, Bao D, Zoll J, Dubois C, Federe GC, Chen L, Joseph SB, Klickstein LB, Walker J, Molteni V, McNamara P, Meeusen S, Tully DC, Badman MK, Xu J, Laffitte B.
Hepatology Comm. 2019 May; 3(8): 1085-1097.

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity.
Ahmed SM, Ramani PD, Wong SQR, Zhao X, Ivanyi-Nagy R, Leong TC, Chua C, Li Z, Hentze H, Tan IB, Yan J, DasGupta R, Dröge P.
PloS one. 2019; 14(5)

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Sellers WR, Lees E, Shao W, Dillon MP, Stuart DD.
Journal of medicinal chemistry. 2019 May;

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab Fragment of NISTmAb.
Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, Park I, Brock A, Lu X, Pandey R, Chandramohan A, Anand GS, Nirudodhi SN, Sperry JB, Rouse JC, Carroll JA, Rand KD, Leurs U, Weis DD, Al-Naqshabandi MA, Hageman TS, Deredge D, Wintrode PL, Papanastasiou M, Lambris JD, Li S, Urata S.
Analytical chemistry. 2019 Jun; 91(11): 7336-7345.

Defects in Efflux (oprM), ?-Lactamase (ampC), and Lipopolysaccharide Transport (lptE) Genes Mediate Antibiotic Hypersusceptibility of Pseudomonas aeruginosa Strain Z61.
Shen X, Johnson NV, Kreamer NNK, Barnes SW, Walker JR, Woods AL, Six DA, Dean CR.
Antimicrobial agents and chemotherapy. 2019 Jul; 63(7)

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK.
Nature communications. 2019 Apr; 10(1): 1523.

Development of a virtual reality platform for effective communication of structural data in drug discovery.
Kingsley LJ, Brunet V, Lelais G, McCloskey S, Milliken K, Leija E, Fuhs SR, Wang K, Zhou E, Spraggon G.
Journal of molecular graphics & modelling. 2019 Jun; 89: 234-241.

Joints in the appendicular skeleton: Developmental mechanisms and evolutionary influences.
Rux D, Decker RS, Koyama E, Pacifici M.
Curr Top Dev Biol. 2019 ; 133: 119-151.

Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes
Huang Z, Tremblay MS, Wu TY, Ding Q, Hao X, Baaten J, Hill R, Liu B, Meeusem S, Zou Y, Yan S, Jia Y, Nguyen-Tran V, Shen W, Bhat G, Glynne R, Laffitte B, Li J, Molteni V, Liu YA.
ACS Omega. 2019 Feb; 4(2): 3571-3581.

A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer.
Lucki NC, Villa GR, Vergani N, Bollong MJ, Beyer BA, Lee JW, Anglin JL, Spangenberg SH, Chin EN, Sharma A, Johnson K, Sander PN, Gordon P, Skirboll SL, Wurdak H, Schultz PG, Mischel PS, Lairson LL.
Proceedings of the National Academy of Sciences of the United States of America. 2019 Mar; 116(13): 6435-6440.

Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
Li Z, Yang F, Xuan Y, Xi R, Zhao R.
Scientific reports. 2019 Mar; 9(1): 3226.

Identification of a Xist silencing domain by Tiling CRISPR.
Wang Y, Zhong Y, Zhou Y, Tanaseichuk O, Li Z, Zhao JC.
Scientific reports. 2019 Feb; 9(1): 2408.

Discovering highly selective and diverse PPAR-delta agonists by ligand based machine learning and structural modeling.
Da'adoosh B, Marcus D, Rayan A, King F, Che J, Goldblum A.
Scientific reports. 2019 Jan; 9(1): 1106.

Combining CDK4/6 inhibition with taxanes enhances anti-tumor efficacy by sustained impairment of pRB-E2F pathways in squamous cell lung cancer.
Cao J, Zhu Z, Wang H, Nichols TC, Lui GYL, Deng S, Rejto PA, VanArsdale T, Hardwick JS, Weinrich SL, Wei P.
Oncogene. 2019 May; 38(21): 4125-4141.

One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2-Sp3 Cross-Coupling.
Koyanagi T, Herath A, Chong A, Ratnikov M, Valiere A, Chang J, Molteni V, Loren J.
Organic letters. 2019 Feb; 21(3): 816-820.

STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice.
Liu X, Wang H, Jiang Y, Zheng Q, Petrus M, Zhang M, Zheng S, Schmedt C, Dong X, Xiao B.
Cell research. 2019 Feb; 29(2): 95-109.

8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity.
Leven M, Held J, Duffy S, Alves Avelar LA, Meister S, Delves M, Plouffe D, Kuna K, Tschan S, Avery VM, Winzeler EA, Mordmüller B, Kurz T.
ChemMedChem. 2019 Feb; 14(4): 501-511.

Enabling drug discovery and development through single-cell imaging.
Pomerantz AK, Sari-Sarraf F, Grove KJ, Pedro L, Rudewicz PJ, Fathman JW, Krucker T.
Expert opinion on drug discovery. 2019 Feb; 14(2): 115-125.

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA.
Nature. 2019 Jan; 565(7738)

Previously Uncharacterized Vacuolar-type ATPase Binding Site Discovered from Structurally Similar Compounds with Distinct Mechanisms of Action.
Wang AC, Pham HT, Lipps JM, Brittain SM, Harrington E, Wang Y, King FJ, Russ C, Pan X, Hoepfner D, Tallarico J, Feng Y, Jain RK, Schirle M, Thomas JR.
ACS chemical biology. 2019 Jan; 14(1): 20-26.

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of ?-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression.
Ranjitkar S, Jones AK, Mostafavi M, Zwirko Z, Iartchouk O, Barnes SW, Walker JR, Willis TW, Lee PS, Dean CR.
Antimicrobial agents and chemotherapy. 2019 Feb; 63(2)

Plasma Protein Binding of Highly Bound Drugs Determined With Equilibrium Gel Filtration of Nonradiolabeled Compounds and LC-MS/MS Detection.
Isbell J, Yuan D, Torrao L, Gatlik E, Hoffmann L, Wipfli P.
Journal of pharmaceutical sciences. 2019 Feb; 108(2): 1053-1060.

 

2018

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA.
Science. 2018 Dec; 362(6419)

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity.
Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, Katibah GE, Kanne DB, Leong JJ, Metchette K, Bruml JR, Ndubaku CO, McKenna JM, Feng Y, Zheng L, Bender SL, Cho CY, Leong ML, van Elsas A, Dubensky TW Jr, McWhirter SM.
Cell Rep. 2018 Dec; 25(11): 3074-3085.e5.

Generation and Cross-Coupling of Organozinc Reagents in Flow.
Herath A, Molteni V, Pan S, Loren J.
Org Lett. 2018 Nov;

Target (MexB) and efflux based mechanisms decreasing the effectiveness of the efflux pump inhibitor D13-9001 in P. aeruginosa PAO1: uncovering a new role for MexMN-OprM in efflux of β-lactams and a novel regulatory circuit (MmnRS) controlling MexMN expression.
Ranjitkar S, Jones AK, Mostafavi M, Zwirko Z, Iartchouk O, Barnes SW, Walker JR, Willis TW, Lee PS, Dean CR.
Antimicrob Agents Chemother. 2018 Nov;

TRIAMF: A New Method for Delivery of Cas9 Ribonucleoprotein Complex to Human Hematopoietic Stem Cells.
Yen J, Fiorino M, Liu Y, Paula S, Clarkson S, Quinn L, Tschantz WR, Klock H, Guo N, Russ C, Yu VWC, Mickanin C, Stevenson SC, Lee C, Yang Y.
Sci Rep. 2018 Nov; 8(1): 16304.

Engineering yeast endosymbionts as a step toward the evolution of mitochondria.
Mehta AP, Supekova L, Chen JH, Pestonjamasp K, Webster P, Ko Y, Henderson SC, McDermott G, Supek F, Schultz PG.
Proc Natl Acad Sci U S A. 2018 Nov; 115(46): 11796-11801.

Plasma Protein Binding of Highly Bound Drugs Determined With Equilibrium Gel Filtration of Nonradiolabeled Compounds and LC-MS/MS Detection.
Isbell J, Yuan D, Torrao L, Gatlik E, Hoffmann L, Wipfli P.
J Pharm Sci. 2018 Oct;

Discovery of actinoplanic acid pathway in Streptomyces rapamycinicus reveals a genetically conserved synergism with rapamycin.
Mrak P, Krastel P, Pivk Lukančič P, Tao J, Pistorius D, Moore CM.
J Biol Chem. 2018 Oct;

Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.
Ting PY, Parker AE, Lee JS, Trussell C, Sharif O, Luna F, Federe G, Barnes SW, Walker JR, Vance J, Gao MY, Klock HE, Clarkson S, Russ C, Miraglia LJ, Cooke MP, Boitano AE, McNamara P, Lamb J, Schmedt C, Snead JL.
Nat Methods. 2018 Oct;

Mammalian cell culture density determination using a laser through-beam sensor.
Rue SM, Anderson PW, Miller JM, Fanale SG, Chang JY, Glaser SM, Lesley SA.
Biotechniques. 2018 Oct; 65(4): 224-226.

Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.
Maritan M, Veggi D, Cozzi R, Dello Iacono L, Bartolini E, Lo Surdo P, Maruggi G, Spraggon G, Bottomley MJ, Malito E.
PLoS One. 2018 ; 13(8)

Structure of the human volume regulated anion channel.
Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Cahalan SM, Qiu Z, Hong G, Crowley CS, Whitwam T, Lee WH, Ward AB, Patapoutian A.
Elife. 2018 Aug; 7

Co-regulatory networks of human serum proteins link genetics to disease.
Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Aspelund T, Shu L, Trifonov V, Sigurdsson S, Manolescu A, Zhu J, Olafsson Ö, Jakobsdottir J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Orth AP, Jennings LL, Gudnason V.
Science. 2018 Aug; 361(6404): 769-773.

Stable nanoemulsions for the delivery of small molecule immune potentiators.
Lodaya RN, Brito LA, Wu TYH, Miller AT, Otten GR, Singh M, O'Hagan DT.
J Pharm Sci. 2018 Jun

A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery.
Joslin J, Gilligan J, Anderson P, Garcia C, Sharif O, Hampton J, Cohen S, King M, Zhou B, Jiang S, Trussell C, Dunn R, Fathman JW, Snead JL, Boitano AE, Nguyen T, Conner M, Cooke M, Harris J, Ainscow E, Zhou Y, Shaw C, Sipes D, Mainquist J, Lesley S.
SLAS Discov. 2018 May; 4294967295.

Preclinical Antitumor Activity of a Novel Anti-c-KIT Antibody Drug Conjugate against Mutant and Wild Type c-KIT Positive Solid Tumors.
Abrams TJ, Connor A, Fanton CP, Cohen SB, Huber T, Miller K, Hong EE, Niu X, Kline J, Ison-Dugenny M, Harris S, Walker DB, Krauser KR, Galimi F, Wang Z, Ghoddusi M, Mansfield KG, Lee-Hoeflich ST, Holash J, Pryer N, Kluwe W, Ettenberg SA, Sellers WR, Lees E, Kwon P, Abraham JA, Schleyer S.
Clin Cancer Res. 2018 May

Recent Progress in Methylation of (Hetero)Arenes by Cross-Coupling or C–H Activation
Liu YA, Yang YB.
Synlett. 2018 May; 29(4): 375-382.

GPR68 Senses Flow and Is Essential for Vascular Physiology.
Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A.
Cell. 2018 Apr; 173(3): 762-4294967295.

Reporter Gene Assays Using Viral Functional Genomics Libraries.
Welch G, Damoiseaux R, Miraglia L.
Methods Mol Biol. 2018 ; 1755: 121-133.

Reporter Gene Assays Using Transfectable Functional Genomics Libraries.
Welch G, Damoiseaux R, Miraglia L.
Methods Mol Biol. 2018 ; 1755: 107-120.

Making It All Work: Functional Genomics and Reporter Gene Assays.
Welch G, Damoiseaux R, Miraglia L.
Methods Mol Biol. 2018 ; 1755: 89-105.

Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M.
Sampath SC, Sampath SC, Ho ATV, Corbel SY, Millstone JD, Lamb J, Walker J, Kinzel B, Schmedt C, Blau HM.
Nat Commun. 2018 Apr; 9(1): 1531.

Total Synthesis of (±)-Minfiensine via a Formal [3+2] Cycloaddition.
Zhang C, Ji W, Liu YA, Song C, Liao X.
J Nat Prod. 2018 Apr; 81(4): 1065-1069.

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.
Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A.
Cell. 2018 Apr; 173(2): 443-4294967295.

The CD11a and Endothelial Protein C Receptor Marker Combination Simplifies and Improves the Purification of Mouse Hematopoietic Stem Cells.
Karimzadeh A, Scarfone VM, Varady E, Chao C, Grathwohl K, Fathman JW, Fruman DA, Serwold T, Inlay MA.
Stem Cells Transl Med. 2018 Jun; 7(6): 468-476.

Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism.
Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP.
Front Psychiatry. 2018; 9: 28.

Protein palmitoylation plays an important role in Trichomonas vaginalis adherence.
Nievas YR, Vashisht AA, Corvi MM, Metz S, Johnson PJ, Wohlschlegel JA, de Miguel N.
Mol Cell Proteomics. 2018 Feb

Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation.
Pham GH, Ou W, Bursulaya B, DiDonato M, Herath A, Jin Y, Hao X, Loren J, Spraggon G, Brock A, Uno T, Geierstanger BH, Cellitti SE.
Chembiochem. 2018 Apr; 19(8): 799-804.

Myoblast fusion confusion: the resolution begins.
Sampath SC, Sampath SC, Millay DP.
Skelet Muscle. 2018 Jan; 8(1): 3.

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.
Velcicky J, Bodendorf U, Rigollier P, Epple R, Beisner DR, Guerini D, Smith P, Liu B, Feifel R, Wipfli P, Aichholz R, Couttet P, Dix I, Widmer T, Wen B, Brandl T.
J Med Chem. 2018 Feb; 61(3): 865-880.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA.
Science. 2018 Jan; 359(6372): 191-199.

The next generation's Frankenstein films.
Nguyen J, Newton MS, Strong M, Pačesa M, Cao B, Winter KA, Dutton-Regester K, Kingsley LJ.
Science. 2018 Jan; 359(6372): 170-171.

Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.
Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC.
Oncoimmunology. 2018 ; 7(2)

Short-term low-dose mTORC1 inhibition in aged rats counter-regulates age-related gene changes and blocks age-related kidney pathology.
Shavlakadze T, Zhu J, Wang S, Zhou W, Morin B, Egerman MA, Fan L, Wang Y, Iartchouk O, Meyer A, Valdez R, Mannick JB, Klickstein LB, Glass DJ.
J Gerontol A Biol Sci Med Sci. 2018 Jan;

 

2000-2017

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
Tully DC, Rucker PV, Chianelli D, Williams J, Vidal A, Alper PB, Mutnick D, Bursulaya B, Schmeits J, Wu X, Bao D, Zoll J, Kim Y, Groessl T, McNamara P, Seidel HM, Molteni V, Liu B, Phimister A, Joseph SB, Laffitte B.
J Med Chem. 2017 Dec; 60(24): 9960-9973.

The microprotein Minion controls cell fusion and muscle formation.
Zhang Q, Vashisht AA, O'Rourke J, Corbel SY, Moran R, Romero A, Miraglia L, Zhang J, Durrant E, Schmedt C, Sampath SC, Sampath SC.
Nat Commun. 2017 Jun; 8: 15664.

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H, Palakurthi S, Jang J, Lelais G, DiDonato M, Bursulaya B, Michellys PY, Epple R, Marsilje TH, McNeill M, Lu W, Harris J, Bender S, Wong KK, Jänne PA, Eck MJ.
Nature. 2016 May; 534(7605): 129-32.

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Khare S, Nagle AS, Biggart A, Lai YH, Liang F, Davis LC, Barnes SW, Mathison CJ, Myburgh E, Gao MY, Gillespie JR, Liu X, Tan JL, Stinson M, Rivera IC, Ballard J, Yeh V, Groessl T, Federe G, Koh HX, Venable JD, Bursulaya B, Shapiro M, Mishra PK, Spraggon G, Brock A, Mottram JC, Buckner FS, Rao SP, Wen BG, Walker JR, Tuntland T, Molteni V, Glynne RJ, Supek F.
Nature. 2016 Sep; 537(7619): 229-233.

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.
Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F.
PLoS Pathog. 2015 Jul; 11(7)

Inhibition of DYRK1A and GSK3B induces human ß-cell proliferation.
Shen W, Taylor B, Jin Q, Nguyen-Tran V, Meeusen S, Zhang YQ, Kamireddy A, Swafford A, Powers AF, Walker J, Lamb J, Bursalaya B, DiDonato M, Harb G, Qiu M, Filippi CM, Deaton L,
Turk CN, Suarez-Pinzon WL, Liu Y, Hao X, Mo T, Yan S, Li J, Herman AE, Hering BJ, Wu T, Martin Seidel H, McNamara P, Glynne R, Laffitte B.
Nat Commun. 2015 Oct; 6: 8372.

Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.(link is external) 
Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, Batalov S, Harris JL, Liu J. 
BMC Cancer. 2014 Dec; 14: 944.

Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis.(link is external)
Nagle AS, Khare S, Kumar AB, Supek F, Buchynskyy A, Mathison CJ, Chennamaneni NK, Pendem N, Buckner FS, Gelb MH, Molteni V. 
Chem Rev. 2014 Nov

Targeting Plasmodium PI(4)K to eliminate malaria. 
McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. 
Nature. 2013 Dec; 504(7479): 248-53.  

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. 
Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, Kowal C, Phung V, Guo G, Wang Y, Graham MP, Flynn S, Brenner JC, Li C, Villarroel MC, Schultz PG, Wu X, McNamara P, Sellers WR, Petruzzelli L, Boral AL, Seidel HM, McLaughlin ME, Che J, Carey TE, Vanasse G, Harris JL. 
Proc Natl Acad Sci U S A. 2013 Dec; 110(50): 20224-9.  

A stem cell-based approach to cartilage repair. 
Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG. 
Science. 2012 May; 336(6082): 717-21.  

Site-specific protein modifications through pyrroline-carboxy-lysine residues. 
Ou W, Uno T, Chiu HP, Grünewald J, Cellitti SE, Crossgrove T, Hao X, Fan Q, Quinn LL, Patterson P, Okach L, Jones DH, Lesley SA, Brock A, Geierstanger BH. 
Proc Natl Acad Sci U S A. 2011 Jun; 108(26): 10437-42.  

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. 
Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. 
Science. 2010 Sep; 329(5997): 1345-8.  

Parallel methods for expression and purification. 
Lesley SA. 
Methods Enzymol. 2009 ; 463: 767-85.  

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. 
Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler EA. 
Proc Natl Acad Sci U S A. 2008 Jul; 105(26): 9059-64.  

Essential role of stromally induced hedgehog signaling in B-cell malignancies. 
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M. 
Nat Med. 2007 Aug; 13(8): 944-51.  

The nuclear receptor LXR is a glucose sensor. 
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E. 
Nature. 2007 Jan; 445(7124): 219-23.  

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. 
Galkin AV, Melnick JS, Kim S, Hood TL, Li N, Li L, Xia G, Steensma R, Chopiuk G, Jiang J, Wan Y, Ding P, Liu Y, Sun F, Schultz PG, Gray NS, Warmuth M. 
Proc Natl Acad Sci U S A. 2007 Jan; 104(1): 270-5.  

An efficient rapid system for profiling the cellular activities of molecular libraries. 
Melnick JS, Janes J, Kim S, Chang JY, Sipes DG, Gunderson D, Jarnes L, Matzen JT, Garcia ME, Hood TL, Beigi R, Xia G, Harig RA, Asatryan H, Yan SF, Zhou Y, Gu XJ, Saadat A, Zhou V, King FJ, Shaw CM, Su AI, Downs R, Gray NS, Schultz PG, Warmuth M, Caldwell JS. 
Proc Natl Acad Sci U S A. 2006 Feb; 103(9): 3153-8.  

Illumination of the melanopsin signaling pathway. 
Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T. 
Science. 2005 Jan; 307(5709): 600-4.  

A gene atlas of the mouse and human protein-encoding transcriptomes. 
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. 
Proc Natl Acad Sci U S A. 2004 Apr; 101(16): 6062-7.  

Genome-scale functional profiling of the mammalian AP-1 signaling pathway. 
Chanda SK, White S, Orth AP, Reisdorph R, Miraglia L, Thomas RS, DeJesus P, Mason DE, Huang Q, Vega R, Yu DH, Nelson CG, Smith BM, Terry R, Linford AS, Yu Y, Chirn GW, Song C, Labow MA, Cohen D, King FJ, Peters EC, Schultz PG, Vogt PK, Hogenesch JB, Caldwell JS. 
Proc Natl Acad Sci U S A. 2003 Oct; 100(21): 12153-8.  

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. 
Wiltshire T, Pletcher MT, Batalov S, Barnes SW, Tarantino LM, Cooke MP, Wu H, Smylie K, Santrosyan A, Copeland NG, Jenkins NA, Kalush F, Mural RJ, Glynne RJ, Kay SA, Adams MD, Fletcher CF. 
Proc Natl Acad Sci U S A. 2003 Mar; 100(6): 3380-5.  

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. 
Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. 
Proc Natl Acad Sci U S A. 2002 Sep; 99(18): 11664-9.  

A heat-sensitive TRP channel expressed in keratinocytes. 
Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A. 
Science. 2002 Jun; 296(5575): 2046-9.  

Substrate specificity of the human proteasome. 
Harris JL, Alper PB, Li J, Rechsteiner M, Backes BJ. 
Chem Biol. 2001 Dec; 8(12): 1131-41.  

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. 
Welsh JB, Zarrinkar PP, Sapinoso LM, Kern SG, Behling CA, Monk BJ, Lockhart DJ, Burger RA, Hampton GM. 
Proc Natl Acad Sci U S A. 2001 Jan; 98(3): 1176-81.  

Genomics, gene expression and DNA arrays. 
Lockhart DJ, Winzeler EA. 
Nature. 2000 Jun; 405(6788): 827-36.